2K Sports Major League Baseball series (MLB 2K) is a series of Major League Baseball video games, developed by Visual Concepts and Kush Games, and published by 2K Games. There have been twelve games in the series. All games were created for each MLB season. The series was created in 2004 after Visual Concepts teamed up with ESPN.

Visual Concepts called the series World Series Baseball in years prior to 2004 for the Dreamcast, with Pedro Martínez as the cover athlete.

However, the future of the MLB 2K series is uncertain, as 2K's Major League Baseball deal will expire in 2012.